Reactogenecity of indigenously produced measles vaccine.

نویسندگان

  • I Bhargava
  • B C Chhaparwal
  • M A Phadke
  • S F Irani
  • B K Chakladhar
  • C P Maheshwari
چکیده

OBJECTIVE To assess the safety and reactogenecity of indigenously produced measles vaccine derived from EZ strain. DESIGN A longitudinal clinical follow up after vaccination. SETTING Hospital based and home follow up, as required. SUBJECTS 12,470 children, 9 to 15 months old, immunized with measles vaccine of EZ strain, in accordance with the National Immunization Schedule, at five centers. METHODS A clinical follow up of children at 1 day, 1 week, 2 weeks, 3 weeks and 6 weeks after measles vaccination. A detailed clinical neurological examination in children showing side effects. RESULTS Mild side effects were documented in 31%. Of these, 90% were seen in the first two weeks, out of which two thirds were seen during the first week. Commonest side effects were coryza (10%), fever (9.8%), cough (3.2%) and diarrhea (3.2%). Convulsions, with no later sequelae were documented in 2 cases only. CONCLUSIONS Measles vaccine manufactured in India, using EZ strain is a safe vaccine. It has a level of reactogenecity including neurological aspects, lower than that reported in India with the Schwarz strain vaccine.

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عنوان ژورنال:
  • Indian pediatrics

دوره 33 10  شماره 

صفحات  -

تاریخ انتشار 1996